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A Skeptical Take of Semaglutide for Cardiac Protection A preventive cardiologist offers a critical appraisal of the SELECT trial of Semaglutide (Wegovy) When the New England Journal of Medicine published the placebo-controlled SELECT trial of semaglutide in patients with established vascular disease, I had thought cardiology had discovered another disease-modifying drug

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Many patients report fuller feelings after smaller meals, reduced hunger between meals, and diminished interest in high-calorie or processed foods

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The SURMOUNT trials demonstrated average weight loss of 20 to 25 percent of body weight, making tirzepatide the more potent option for many patients