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Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids

However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)

Y.VaradharajS.ReyesL

Notably, these mitochondrial benefits occurred without increasing mitochondrial number, suggesting improved function rather than quantity [76]

As an organ responsible for metabolite excretion and reabsorption, the kidney is highly susceptible to disruptions in the redox balance

Gastroenterology 164, 10691085