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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)

Nausea and GI upset

Here are some suggestions on how to incorporate the medicine into your daily routine: 1

Given that GLP-1-MK-801 still leads to lean mass loss and food aversion (rather than just satiety), the drug appears to have some undesirable aspects

Finally, the importance of gut peptides on gut microbiota was discussed

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