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Injection technique optimization includes: Site rotation systematically alternating injection locations to prevent tissue trauma and lipohypertrophy Proper administration following the manufacturer's Instructions for Use for Mounjaro or Zepbound pens regarding proper technique Room temperature medication allowing the pen to reach room temperature before injection reduces discomfort Skin preparation cleaning the injection site with alcohol and allowing it to dry completely Avoiding scarred or damaged skin selecting healthy tissue free from previous reactions, bruising, or inflammation For mild injection site reactions, conservative management is typically sufficient
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