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These modifications include an Ala8Aib amino acid substitution and attachment of a C18 fatty diacid side chain at Lys26 via a linker that promotes albumin binding, significantly prolonging circulation time compared to native GLP-1

Impact of physical activity on glycemic control and prevalence of cardiovascular risk factors in adults with type 1 diabetes: a cross-sectional multicenter study of 18,028 patients

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Some patients report fatigue during tirzepatide treatment, particularly during the early treatment phase or with dose escalation, though this is not among the most common adverse events in clinical trials

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Clinical trials lasting up to 52 weeks have shown a reduction in HbA1c levels of approximately 1% with DPP-4 inhibition (18)