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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Provenzano D, Washington SD, Baraniuk JN

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Furthermore, although the two domains of the Fv fragment, V L and V H , can be coded for by separate genes, they can be joined, using recombinant methods, by a synthetic linker that enables them to be made as a single protein chain in which the V L and V- regions pair to form monovalent molecules (known as single chain Fv (scFv)

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