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This study aimed to assess the impact of these barriers in obese adults with type 2 diabetes treated with a GLP-1 receptor agonist (GLP-1RA) and compare them against other glucose-lowering agents in a real-world setting

These results are parallel to, and consistent with, the aforementioned effects on insulin

On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

GLP-1 receptor agonists and cardiovascular disease in patients with type 2 diabetes

(1) patients with DKD without SGLT2is and DPP4is, (2) those with DKD taking SGLT2is alone, and (3) those with DKD taking both of SGLT2is and DPP4is

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