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4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation

Tirzepatide starts at $215/month: $195/month (3 months, $585 total save $60), $190/month (6 months, $1,140 total save $150), and $186/month (12 months, $2,232 total save $348)

The tirzepatide clinical data consistently shows superior results in this range

If side effects like nausea or fatigue appear, doctors may pause or lower the dose temporarily before slowly increasing it again
Still, not all individuals who are obese will develop diabetes, and some who are of a healthy weight will nevertheless get the disease