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For heavy smokers, higher nicotine levels (like 12-20 mg/mL) might be appropriate, while lighter smokers might opt for lower doses

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To mitigate this, future studies should consider incorporating objective biomarkers of nicotine exposure, such as cotinine levels in blood or urine, to provide a more accurate assessment of tobacco use and minimize the risk of reporting bias

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That said, the negative health consequences of smoking far outweigh any metabolic benefit