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We spoke with three doctors who specialize in weight loss and prescribe these medications

10.1111/obr.13704 Obes Rev

Quick Answer: Semaglutide is not metabolized by CYP450 enzymes When starting semaglutide, most clinicians cut the patients mealtime (prandial) insulin dose by 20 to 30% as a starting point, with further adjustments based on glucose monitoring over the first 1 to 2 weeks

It has been proposed that the loss of protective immunologic factors and increased cellular stress responses lead to heightened peripheral afferent nerve excitability and detrusor overactivity [53]

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It's important to understand that stopping semaglutide does not cause immediate weight gain, but it removes a significant tool that was helping to maintain weight loss