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In a study of more than 1,600 adults with type 2 diabetes, those who received the highest dose of orforglipron on average shed 10.5% of their weight.

No significant differences were observed for myocardial infarction, stroke, or revascularization with risk differences of 0.1% (95% CI 1.0 to 0.8%), 0.8% (95% CI 0.2 to 1.7%), and 0.2% (95% CI -0.71.1%), respectively

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