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however, some authors perform these tests to improve the accuracy in identifyng the medication that triggers DRESS, considering them potentially useful and safe when performed by specialists.58,62 It should be noted that, despite the small doses used, at concentrations lower than in patch testing, serious and even fatal reactions have occurred and European guidelines still contraindicate it.63 Therefore, the indication of IDT must be carefully evaluated and is of great importance in reactions caused by antibiotics, due to the possibility of cross-reaction between them.58,62 Certain precautions are important when carrying out IDT in patients with DRESS: i) Tests with medications must be carried out in a hospital environment (under supervision) and can only be carried out with commercially available drugs in injectable form

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Signature Z-strap design distributes weight and locks heel in place Cushioned midsole absorbs impact on uneven terrain Grippy rubber outsole for wet and dry traction Adjustable webbing straps for custom fit Quick-drying construction ideal for water exposure

Bottoms are best paired with tailored trousers