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OHB signaling via GPR109A also regulates inflammation via NLRP3 (NOD-,LRR-and pyrin domain-containing protein 3) (Macia et al., 2015), reverse cholesterol transport (Wu and Zhao, 2009), atherosclerosis (Zhang et al., 2021) and neuroprotection (Rahman et al., 2014)
Consequently, findings from SH-SY5Y cells may not fully translate to in vivo conditions or capture the complex pathophysiology of the human brain
Y.SinghM.ShinY.-K.KimJ.KumbrinkJ.et al (2013)
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