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Description
What This Means for Future Treatment Although retrospective, this evidence highlights the strong potential benefit of GLP-1 RAs in MPNs and MDS

Additional studies with different active comparators will further expand our understanding of the differences in efficacy and tolerability within this class of agents

The Risks Another challenge with GLP-1 use in someone with type 1 diabetes is the potential risk of hypoglycemia, or low blood sugar

Novo Nordisks semaglutide is expected to lose its patent protection in Canada, Brazil, India, and China in 20252026

3 The coexistence of obesity and T2DM markedly amplifies cardiovascular risk and contributes to poor BP control in clinical practice

Costs remain a major barrier, particularly for semaglutide and tirzepatide, while liraglutide has become more affordable since its patent expired
