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All SAEs will be followed up until satisfactory resolution or until the treating physicians and the principal investigator deem the event to be chronic or the participant to be stable

Treatments with a family of lipid-lowering drugs known as fibrates (e.g., fenofibrate, bezofibrate) have been associated with an increased excretion of betaine in the urine and a rise in homocysteine concentration in the blood of patients with diabetes mellitus or metabolic syndrome (125, 126)

Initially, lipoxygenases (LOXs) extract a hydrogen atom from the diallyl position of a PUFA, resulting in the formation of a phospholipid radical (PL)

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