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10.1093/eurheartj/ehr309

Mechanisms involved in the side effects of glucocorticoids

Temporarily reducing the GLP-1 medication dose or extending the titration schedule may allow better tolerance while maintaining therapeutic benefits

It's a signal that the population most likely to seek GLP-1 therapy for cosmetic and metabolic weight goals (rather than diabetes management) may be the population bearing the greatest skeletal cost

Shorter courses produce less total weight loss and may not allow enough time for metabolic adaptation

Intimately familiar with the amino acid structure of glucagon, Mojsov had a hunch that the active part of GLP-1 might in fact be located in a small stretch of the peptide