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doi: 10.1172/JCI13300

55 Research has shown that individuals with renal hypouricemia and loss-of-function mutations in URAT1 demonstrate incomplete responses to both pyrazinamide and uricosurics, resulting in average concentrations reaching 0.93 mg/dL

doi: 10.3746/jkfn.2016.45.10.1508

[14] AOD9604 AOD9604 is a peptide fragment of the human growth hormones (hGH) C-terminus, which harbors the fat reducing activity of hGH without the negative effects

corroborated by Oostdyk 2024) and downregulates surface GLP-1R within 12 hours at physiological albumin (Hinds 2024), so the sustained signal held against that fade, set by dose, is what carries the effect