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First, none of the trials included HF as a component of the primary composite endpoint (usually 3-component MACE)

doi: 10.1111/j.1365-2567.2011.03506.x 43 YustaBBaggioLLKoehlerJHollandDCaoXPinnellLJet al

With inadequate water in the body, stools can become dry and hard and difficult to pass

GLP-1 is a hormone that your small intestine makes

Sweeting AN, Caterson ID

Effects of canagliflozin on amputation risk in type 2 diabetes: the CANVAS Program
