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Methods: Two-sample Mendelian randomization study was conducted

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doi: 10.1016/j.yebeh.2015.03.003 79

Nevertheless, this latter in vivo study demonstrates that homocysteine ingestion in rat stimulates, in a dose-dependent manner, the transcription of aortic cyclin-dependent kinase, which is required for the mitosis and subsequent proliferation of vascular smooth muscle cells

More specifically, IGF-1 LR3 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, and a 13 amino acid extension peptide at the N terminus from methionyl porcine Growth Hormone [1]