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Niacin soaks up excessive methyl groups in people that over methylate is and for some rare individuals very high doses of niacin and have powerful therapeutic effects

[DOI] [PubMed] [Google Scholar] 68.Jelovac N., Sikiric P., Rucman R., Petek M., Marovic A., Perovic D., Seiwerth S., Mise S., Turkovic B., Dodig G., et al

doi: 10.1038/nm820 57 SchulmanIG

Have certain medical conditions: Problems that can restrict vitamin B12 absorption include pernicious anemia (a rare autoimmune disease that keeps the body from making a protein necessary to absorb B12), digestive illnesses, such as celiac and Crohns diseases, and immune disorders such as lupus, among others