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Additionally, the proportion of exposure variance explained by instrumental variables was evaluated using R 2 , computed as R 2 = 2 EAF (1 EAF) 2 , where EAF denotes the effect allele frequency of the exposure

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In the book, Kessler acknowledges that you can't really separate those unpleasant feelings from the effective mechanism of the drugs themselves

These symptoms are often observed during the initial weeks of treatment