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The result: Increased glucose-dependent insulin secretion Reduced glucagon release Better control of fasting & postprandial glucose Weight-neutral therapy with minimal risk of hypoglycemia A simple yet effective mechanism that plays a powerful role in modern diabetes management

Demand for these drugs has increased rapidly in recent years, as indications have expanded, but they remain expensive

### Funding Statement SDL and AC were supported by the National Science Foundation (Grant Nos.\ CAREER DMS-1944574 and DMS-2325258) ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained

RELEVANCE: Older adults are at higher risk of frailty, sarcopenia, dehydration, and nutritional decline

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