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This is a life-threatening clinical-dermatological emergency that presents with a variety of symptoms and signs, including skin rash (especially of the exanthema type), which may be accompanied by fever, lymphadenomegaly, hepatitis, hematological (especially atypical lymphocytes and eosinophilia), renal, cardiac, pulmonary and pancreatic changes.1 The term DRESS was initially proposed by Bocquet et al., in 1996, in a review article on the drug hypersensitivity syndrome, which had been previously described under several different terms or synonymies, such as dapsone syndrome, anticonvulsant hypersensitivity syndrome, hydantoin syndrome, and allopurinol hypersensitivity syndrome, depending on the pharmacological agent involved, throughout the 20th century.2 The first case description compatible with DRESS was reported by Myers et al., in 1937

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The reactivation of viruses from the Herpesviridae family (HHV-6, HHV-7, CMV and EBV) is not considered in the first two criteria, only in J-SCAR.2,15,32,49 Bocquet's criteria (1996) are the easiest to apply, as they comprise the presence of three parameters: i) Skin lesions