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The analgesic effect has been studied in different pain models such as: monoiodoacetate osteoarthritis (MIA), neuropathies due to chronic constriction of the sciatic nerve (CCI) and antineoplastic drugs (oxaliplatin and paclitaxel) (Tenci et al., 2017), and by LPS (Singh et al., 2020), where different maca preparations were administered orally
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During pyroptosis, GSDMD-N inserts into the cell membrane, forming cytotoxic pores that compromise membrane integrity and facilitate the release of inflammatory mediators (32)
L., Cooper, C
R., Liu J., Albertini A., Zucca F
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