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Since GLP-1 antagonists slow digestion, they may worsen certain gastrointestinal conditions

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although TriNetX is globally available in 21 countries, the majority of patients (in excess of 90%) are within the United States

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For patients with a proctitis phenotype, suppository therapy is usually more effective than oral therapy and reducing the suppository therapy to three times a week when well can often lead to success in achieving a balance between receiving therapy and the inconvenience of rectal preparations