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However, the body is generally very efficient at excreting excess B12 through urine without any issues

It is one of the most-studied compounds in dermatology and matrix-biology research literature, frequently referenced in pre-clinical models of extracellular-matrix remodelling and gene-expression studies

doi: 10.3389/fimmu.2021.679973 73 AnthonyRMKobayashiTWermelingFRavetchJV

During rapid weight loss, however, demand may exceed endogenous synthesis capacity

Consequently, researchers employ it to explore electron-transport organisation, bioenergetics, and redox pathways in model systems

These microbiome changes reversed rapidly, however, when the obese mice were returned to a normal, lean diet 79