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A., Linetzky B., Le Roux C

Low-density lipoprotein cholesterol (LDL-C) reductions are more modest, generally in the range of 2-10%, though some patients experience more substantial decreases

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However, the absence of clinical benefit suggests that these biological effects are insufficient to alter disease progression on their own

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Look AHEAD Research Group , EightYear Weight Losses With an Intensive Lifestyle Intervention: The Look AHEAD Study, Obesity 22 (2014): 513