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All participants received tirzepatide once weekly for 36 weeks as an adjunct to a reduced-calorie diet and increased physical activity during a lead-in period

You do not need to taper semaglutide before switching

Regarding renal function, no dose adjustment is required for patients with renal impairment, including those with end-stage renal disease

The estimated mean change in HbA1c level was -2.01%, -2.24%, and -2.30% with tirzepatide at doses of 5 mg, 10 mg, and 15 mg respectively, compared to -1.86% with semaglutide