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1 Introduction N-acetylcysteine (NAC), an acetylated derivative of L-cysteine, serves as a precursor of glutathione (GSH), a key pulmonary antioxidant

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Given the variable responses observed following subcutaneous administration and the known bioavailability limitations of GPX4 inhibitors, we also tested intratumoral delivery of RSL3 (volume 100 l, 0.625 mg/injection) (Figure S3G)

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10.1097/nen.0b013e31802c396b J

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doi:10.1016/j.bjorl.2015.04.015 Bigelow RT, Semenov YR, du Lac S, Hoffman HJ, Agrawal Y

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