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Structured programs incorporating medical nutrition therapy, supervised exercise regimens, behavioral counseling, and sleep optimization can substantially enhance medication effects

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Appetite Reduction Tirzepatide and Semaglutide enhance GLP-1 activity, boosting insulin production and reducing appetite

In addition, obesity-associated adipose tissue inflammation further exacerbates CNS inflammation, creating a vicious cycle of metabolisminflammationneurodegeneration (Chen et al., 2024