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Efpeglenatide: The AMPLITUDE-O trial (2021) demonstrated a 27% MACE reduction (HR 0.73, 95% CI 0.580.92) in 4076 T2DM patients, with significant reductions in stroke and HF events [19]

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Long-Term Metabolic Impact Surgery induces metabolic changes that improve insulin sensitivity, reduce inflammation, and reset the bodys weight set point. These effects are longer-lasting and more profound than those from medication alone

And the accumulated gas creates pressure in the stomach and upper digestive tract that has to be released through burping

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Between December 2025 and January 2026, both of these MDLs gained new plaintiffs