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While data from a RCT controls for many of the potential confounding factors, using data from non-primary endpoints requires caveats
118-123 Specifically, Fitzgerald et al

doi: 10.1074/jbc.M110.113613
[PubMed] [Google Scholar] 80.Mihovil I, Radic B, Brcic I, Drmic D, Vukoja I, Boban Blagaic A, et al

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Estrogen level fluctuates during that time of the month, causing swelling
