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However, body composition changes from successful fat loss can affect insulin sensitivity independently

Exercise and circulating insulin-like growth factor I

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[DOI] [PubMed] [Google Scholar] 182

Insulin-like growth factor-1 and lipid metabolism IGF-1 promotes preadipocyte differentiation [181], however, as preadipocytes differentiate, they stop expressing IGF-1Rs, delegating such functions now to insulin receptors, which increase in number significantly

Ulaner GA, Sobol NB, ODonoghue JA, Kirov AS, Riedl CC, Min R, et al