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According to FDA labeling, no dose adjustments are generally required for patients with hepatic impairment

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Patients using both medication classes together often achieve HbA1c reductions of 1.5% to 2.0%substantially more than either medication alone

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267 Conclusion In conclusion, the regulation of metabolic homeostasis is a multifactorial, complex process, with the synergistic activity of the incretin effect and the pancreatic islets being integral for this being achieved

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