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This explains why gut-expressed receptors respond to the compound even before its absorbed systemically

Neurodegenerative diseases T2D is a risk factor for cognitive dysfunction and for developing Alzheimers disease (62)

The Rise of GLP-1 Agonists The rapid ascent of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as Novo Nordisks Ozempic and Wegovy, and Eli Lilly & Co.s Mounjaro and Zepbound has revolutionized diabetes management and weight loss

therefore, adopting strategies to minimize muscle and bone loss is prudent

In addition, the ICV infusion of exendin-4 increases CNS activity, promotes BAT activation and white adipose tissue browning, and increases BAT glucose and triglyceride uptake [27]