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Note: Rescue medication = use of new anti-diabetic medication as add-on to treatment and used for more than 21 days with the initiation at or after randomization and before last day on treatment

Congenital conditions like Downs syndrome or Angelmens syndrome may cause them in children or adults, as well as head trauma

The third receptor in Retatrutides triple agonist mechanism, responsible for thermogenesis effects

This approach dramatically reduces the risk of degradation from repeated freeze-thaw cycles, which can physically damage peptide chains or promote aggregation (3)

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Mounjaros dual mechanism (GLP-1 and GIP) may cause slightly more pronounced digestive effects than single-action medications like Ozempic