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This dysbiotic state, strongly promoted by a HFD, compromises the intestinal mucus layer and weakens tight junction integrity, leading to increased intestinal permeability (leaky gut) (90, 93, 94)

But standard physical function measures like chair rise and gait speed did not change or improved slightly with semaglutide

Moreover, studies show consistent effects on insulin dynamics, lipid handling, and energy regulation in controlled research settings

The higher the body fat mass, the higher was insulin response to GLP infusion

But Ozempic may also heighten the risks of pancreatitis, kidney failure, and thyroid cancer