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Patients following such a diet, should be advised to take oral vitamin B 12regularly

When calorie intake drops, as it reliably does on tirzepatide, the body mobilizes stored triglycerides from adipose tissue

They could not determine whether obesity lowers B12 levels or if low B12 levels predispose someone to obesity

doi: 10.3389/fmolb.2016.00027

The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that regulate the transcription of genes involved in energy production, lipid metabolism, and inflammation

A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)