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This potential neurohumoral factor with strong antidiabetic effects does not appear to require normal pituitary function since hypophysectomy did not abolish the normalization in glucose levels during CNS leptin infusion in type-1 diabetic animals [51]

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doi: 10.1093/neuonc/noz028

ADI deiminates arginine to citrulline and ammonia

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Effect of urea surface modification and photocatalytic cleaning on surface-assisted laser desorption ionization mass spectrometry with amorphous TiO2 nanoparticles
