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HDL cholesterol modestly increased across the dose range, while LDL cholesterol showed minimal change a pattern consistent with weight-mediated lipid improvements rather than direct drug effects on LDL pathways
Recommendations: Maintain consistent hydration Monitor persistent GI symptoms Replenish electrolytes when clinically indicated Severe or prolonged symptoms require medical review

Vomiting combined with constipation can indicate bowel obstruction, particularly if accompanied by abdominal swelling and inability to pass gas

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