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While KEAP1 (12%) and NRF2 (15%) mutations were found in a much lower percentage of samples, gene mutations related to the KEAP1NRF2 system, including CUL3 (7%) and PTEN (8%), were more frequent than those in the second most frequently mutated gene CDKN2A (15%)

Nature 451 , 708U4 (2008)

Genetics of migraine: Where are we now

Wernersson, S
The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

Physical exercise in major depression: reducing the mortality gap while improving clinical outcomes