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Beyond the occurrence as a product of cellular redox stress, l-2HG also plays a role in plants and eukaryotic cells as part of the mitochondrial metabolic repair mechanism (Hdig et al., 1997

Systematic review of N-acetylcysteine in cystic fibrosis

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Exogenous ROS can be generated by environmental pollutants, such as heavy metals (33), ultraviolet radiation (34), asbestos (35), sulfur dioxide (36), and particulate matter with a diameter of less than 2.5 m (PM2.5) (37)

Kyoung Kim H, Kyoung Kim Y, Song IH, Baek SH, Lee SR, Hye Kim J, Kim JR

H., Liedorp, P