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Semaglutide may also attenuate muscle atrophy in obesity by inhibition of UPS, the central proteolytic machinery of mammalian cells and the crucial regulators of ubiquitin-mediated skeletal muscle protein degradation, the ligases atrogin-1 and MuRF-1

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The Consolidated Criteria for Reporting Qualitative Studies (COREQ) checklist were followed, which is found in the supplementary material (p6)

[DOI] [PubMed] [Google Scholar] 118.Degn K.B., Juhl C.B., Sturis J., et al

This can provide more stable drug levels and potentially allow a lower total weekly dose while maintaining adequate appetite suppression

Published December 11, 2025