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Conclusion: Our study provides the first report on the genetic diversity and transmission dynamics of P

Iron metabolism, free radicals, and oxidative injury

It acts as a scavenger for reactive oxygen species (ROS) and a regulator of the redox state, which is crucial for cell survival and proliferation

The overall evidence indicates that the lifespan in canids is shaped not simply by ROS production, but by the balance between oxidative damage, antioxidant defenses, and repair mechanisms, with artificial selection introducing additional complexity compared to wild relatives

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Li Y, North RY, Rhines LD, Tatsui CE, Rao G, Edwards DD, et al