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Thyroid (2003) 13(9):84550

Seek medical help for severe or persistent symptoms, like abdominal pain or dehydration

Romariz LM, de Melo AAC, Finnegan E, Mesquita Y, Janovsky C

In three nested casecontrol studies from England and Wales, involving 440,089 patients with T2DM and without ASCVD treated with non-insulin glucose-lowering medication, combined SGLT2i and GLP-1RA therapy used for primary prevention was associated with 30% lower odds of MACE (defined as myocardial infarction/acute coronary syndrome, stroke/transient ischemic attack, and/or cardiovascular death) compared with other combination regimens (OR, 0.70

This is concerning because loss of skeletal muscle can lead to decreased strength, reduced functional capacity, and a lower resting metabolic rate, potentially making weight regain more likely after medication discontinuation

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
