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40 Insulin receptor is expressed in skeletal muscle, adipocytes, kidneys, brain, blood vessels, heart, liver, pancreatic endocrine cells (such as islet alpha and beta-cells), bone and the GIT
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However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans
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