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This understanding is in line with the chronotropic effects of GLP-1 RA treatment, which in a large meta-analysis was shown to be associated with heart rate increases of up to 3.35 beats/min (Sun et al., 2015)
[DOI] [PubMed] [Google Scholar] 29.Guccio N, Gribble FM, Reimann F (2022) Glucose-dependent insulinotropic polypeptide-a postprandial hormone with unharnessed metabolic potential
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Gut 2025;74:284-94.ArticlePubMed 102
Tapering Protocol: To mitigate this, Iyengar suggested considering a dose taper over at least 20 weeks
J Biol Chem 270: 26488-26496, 1995
