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For instance, liraglutides effect on GABA transmission in the hippocampus has been shown to require an intact synaptic network, as blocking the generation and propagation of action potentials abolished liraglutide-induced enhancement of GABAergic activity (104)

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However, in isolated mouse hearts perfused with the sAC inhibitor KH7, we observed loss of cardioprotection with GLP-1(2836), but not GLP-1, as measured by LVDP at the end of the reperfusion (25.2 1.7 mmHg, n = 3, vs
