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The amino acid sequence of liraglutide is 97% homologous to GLP-1, and the lysine at position 26 is connected to a 16-carbon fatty acid, which not only enhances the resistance of liraglutide to the degradation of DPP-4, but also provides a slow release effect, extending the half-life to 10~14 h

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These medications are contraindicated in people with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2

7 Recent data shows that GIP is responsible for a substantial portion of postprandial insulin secretion in T2DM and mild hyperglycemia in early disease

Clinical trials show slightly greater average weight loss with tirzepatide, and individuals with genetic predispositions toward GIP-pathway activation often respond more robustly

doi: 10.1210/en.2002-0068 114 KimSJWinterKNianCTsuneokaMKodaYMcIntoshCH