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It is classified as a multi-receptor peptide agonist because it has been studied for activity across three related receptor systems: the glucose-dependent insulinotropic polypeptide receptor, the glucagon-like peptide-1 receptor, and the glucagon receptor

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However, this interaction was not required for small molecule agonist TT-OAD2 that elicited cAMP signaling without the presence of an ECD 14

Achievements, challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS)